Follastatin 344 (& 315): Potent Myostatin Inhibitor  Purity: 98% (HPLC on request)     Sequence: 344 & 315 Amino Acid variations available
MolecularStructure Description
Follistatin 344 is a naturally occurring human peptide and a potent inhibitor of myostatin. Myostatin encourages the degradation of myotubes (skeletal muscle fibers) therefore inhibition of myostatin will ultimately result in increased muscle mass by preventing degradation.Follistatin is being studied for its role in regulation of muscle growth, as an antagonist to myostatin (also known as GDF-8, a TGF superfamily member). Lee & McPherron demonstrated that inhibition of GDF-8, either by genetic elimination (knockout) or by increasing the amount of follistatin, resulted in greatly increased muscle mass.In 2009, research with macaque monkeys demonstrated that regulating follistatin via gene therapy also resulted in muscle growth and increases in strength.A study has also shown that increased levels of follistatin, by leading to increased muscle mass of certain core muscular groups, can increase life expectancy in cases of spinal muscular atrophy (SMA) in animal models.It is also being investigated for its involvement in polycystic ovary syndrome (PCOS), though there is debate as to its direct role in this infertility disease.Download this information